Motif ID: HOX{A4,D4}.p2

Z-value: 1.324


Transcription factors associated with HOX{A4,D4}.p2:

Gene SymbolEntrez IDGene Name
HOXA4 3201 homeobox A4
HOXD4 3233 homeobox D4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXD4chr2_+_176724358-0.486.0e-02Click!
HOXA4chr7_-_27136876-0.411.1e-01Click!


Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_96471544 1.886 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr10_+_11087345 1.470 CELF2
CUGBP, Elav-like family member 2
chr3_-_74652952 1.238 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr5_+_140703784 1.195 NM_018916
NM_032011
PCDHGA3

protocadherin gamma subfamily A, 3

chr8_-_28403652 1.030 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr8_-_42353719 1.020 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr17_+_46176105 1.006 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr3_+_186563529 0.978 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr10_+_11087259 0.967 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr5_-_132228375 0.923 NM_005260
GDF9
growth differentiation factor 9
chr18_+_18989786 0.897 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr12_-_25597444 0.876 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr2_+_202379442 0.868 NM_139158
CDK15
cyclin-dependent kinase 15
chr11_-_117589283 0.829 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr17_+_23818922 0.780


chr10_-_69125932 0.768 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_-_205161821 0.759 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr10_+_11087280 0.757 CELF2
CUGBP, Elav-like family member 2
chr10_+_68355797 0.756 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr22_+_21116283 0.751


chr4_+_109033868 0.739 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr7_+_1239078 0.737 NM_001080461
UNCX
UNC homeobox
chr1_+_63861474 0.733 NM_001172818
PGM1
phosphoglucomutase 1
chr10_-_92671005 0.729 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_-_47909001 0.727 MAP4
microtubule-associated protein 4
chr7_+_128802719 0.726 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr5_-_135318420 0.709 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr1_-_109201228 0.708 NM_152763
AKNAD1
AKNA domain containing 1
chr2_+_17861266 0.686 NM_001105569
MSGN1
mesogenin 1
chr8_+_1940282 0.678 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr13_-_32678142 0.650 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr5_+_140537554 0.646 NM_019120
PCDHB8
protocadherin beta 8
chr5_+_140848905 0.645 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr5_+_140762551 0.631 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr4_-_38460983 0.624 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr18_+_59374372 0.616 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr16_+_4361775 0.609 NM_138440
VASN
vasorin
chr5_-_14706486 0.604


chr8_-_17787342 0.601 FGL1
fibrinogen-like 1
chr1_+_198263352 0.596 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr5_+_140719773 0.594 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr14_-_37133927 0.592 FOXA1
forkhead box A1
chr6_-_32892705 0.591 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr4_+_151722526 0.583 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr11_+_71605466 0.569 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr19_+_54128750 0.568 NM_014475
DHDH
dihydrodiol dehydrogenase (dimeric)
chr13_+_45174446 0.567 NM_152719
SPERT
spermatid associated
chr14_-_37134050 0.566 FOXA1
forkhead box A1
chr12_+_31691360 0.557 NM_001135864
METTL20
methyltransferase like 20
chr17_-_36418869 0.554 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr15_+_46200460 0.553 NM_205850
SLC24A5
solute carrier family 24, member 5
chr5_+_125723686 0.552 NM_001146319
GRAMD3
GRAM domain containing 3
chr1_+_171871283 0.547 NM_001195190
LOC730159
hypothetical protein LOC730159
chr6_-_116973465 0.545 NM_001139444
BET3L
BET3 like (S. cerevisiae)
chr1_-_159191184 0.532 NM_080878
ITLN2
intelectin 2
chr4_-_123761615 0.531 NM_021803
IL21
interleukin 21
chr15_-_41664335 0.520 NM_014659
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chr3_-_49204294 0.512 NM_001080528
LOC646498
hypothetical protein LOC646498
chr3_+_122794859 0.506 NM_016298
FBXO40
F-box protein 40
chr1_+_205328834 0.505 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr10_-_92670764 0.504 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr12_+_53178834 0.501 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr13_+_112746908 0.492 MCF2L
MCF.2 cell line derived transforming sequence-like
chr11_+_73034870 0.488 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr7_-_91632525 0.485 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr1_+_556968 0.485


chr12_+_100394787 0.483 NM_152323
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr17_-_36779399 0.480 NM_002279
KRT33B
keratin 33B
chr7_-_107230867 0.476 NM_000111
SLC26A3
solute carrier family 26, member 3
chr1_-_108032645 0.474 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr1_+_159943385 0.473 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr10_+_124310170 0.469 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr14_+_69307914 0.468 SRSF5
serine/arginine-rich splicing factor 5
chr12_-_7793335 0.464 NM_130441
NM_203503
CLEC4C

C-type lectin domain family 4, member C

chr17_-_44400952 0.462 NM_004123
GIP
gastric inhibitory polypeptide
chr13_+_92677012 0.461 NM_005708
GPC6
glypican 6
chr1_+_148511806 0.460 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr11_+_69176391 0.459 CCND1
cyclin D1
chr4_-_72868598 0.458 NM_000583
GC
group-specific component (vitamin D binding protein)
chr17_-_59825221 0.456


chr4_-_41579325 0.455


chr7_+_128099581 0.454 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr5_-_74362479 0.454 NM_016591
GCNT4
glucosaminyl (N-acetyl) transferase 4, core 2
chr8_+_54926920 0.453 NM_170587
RGS20
regulator of G-protein signaling 20
chr1_+_239882202 0.450 NM_144625
WDR64
WD repeat domain 64
chr16_-_80602546 0.446 NM_145168
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
chr1_-_199348316 0.445 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr5_+_156628929 0.444 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr13_-_96444604 0.443 NM_080818
OXGR1
oxoglutarate (alpha-ketoglutarate) receptor 1
chr4_-_120462705 0.441 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr14_-_37134191 0.440 NM_004496
FOXA1
forkhead box A1
chr11_-_8921155 0.436 NM_020646
ASCL3
achaete-scute complex homolog 3 (Drosophila)
chr17_-_36209672 0.435 NM_181535
KRT28
keratin 28
chr4_-_41445479 0.435 PHOX2B
paired-like homeobox 2b
chr11_+_4466684 0.433 NM_001005171
OR52K1
olfactory receptor, family 52, subfamily K, member 1
chr3_-_57209319 0.432 NM_003865
HESX1
HESX homeobox 1
chr7_+_128136347 0.429 FAM71F1
family with sequence similarity 71, member F1
chr10_+_111755715 0.428 NM_019903
ADD3
adducin 3 (gamma)
chr11_-_7917642 0.425 NM_001003745
OR10A3
olfactory receptor, family 10, subfamily A, member 3
chr5_+_149549712 0.425 NM_014228
SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr9_+_2611740 0.425 NM_001018056
NM_003383
VLDLR

very low density lipoprotein receptor

chr9_+_109131814 0.424 RAD23B
RAD23 homolog B (S. cerevisiae)
chr11_+_113280727 0.424 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr11_-_67207112 0.421 RPL37
ribosomal protein L37
chr5_+_159589014 0.419 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr15_+_60146467 0.418 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr17_-_36276987 0.416 NM_000223
KRT12
keratin 12
chr17_+_38256710 0.416 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr1_+_150005754 0.415 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chr6_-_22410993 0.415 NM_001163558
PRL
prolactin
chr4_+_15080586 0.414 NM_001080522
NM_001164720
NM_020785
CC2D2A


coiled-coil and C2 domain containing 2A


chr7_-_92693716 0.411 NM_001039372
HEPACAM2
HEPACAM family member 2
chr12_-_2814410 0.408 NM_031474
NRIP2
nuclear receptor interacting protein 2
chr15_-_41195994 0.407 RPS3A
ribosomal protein S3A
chr2_+_86998248 0.407 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr18_+_606671 0.406 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr12_+_27740694 0.406 NM_001029874
REP15
RAB15 effector protein
chr11_-_64484184 0.405 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr10_+_86121526 0.403 FAM190B
family with sequence similarity 190, member B
chr17_-_53976681 0.403 NM_001038704
C17orf47
chromosome 17 open reading frame 47
chr1_-_150328153 0.403 NM_001008536
TCHHL1
trichohyalin-like 1
chr6_-_89984214 0.401 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr1_+_109450116 0.400


chr17_+_41424665 0.400 MAPT
microtubule-associated protein tau
chr17_-_23151522 0.400 NOS2
nitric oxide synthase 2, inducible
chr6_-_117853710 0.397 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr3_-_152585226 0.397 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr12_-_66933492 0.395 NM_020525
IL22
interleukin 22
chr1_+_156416360 0.393 NM_001766
CD1D
CD1d molecule
chr12_-_10215942 0.392 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr2_-_20390601 0.391 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr7_-_143622188 0.391 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr1_-_153107084 0.389


chr6_-_31007905 0.388 NM_205854
SFTA2
surfactant associated 2
chr5_+_140790510 0.386 PCDHGA12
protocadherin gamma subfamily A, 12
chr7_+_94953148 0.383 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr19_+_14460757 0.382 NM_001146693
LOC100130932
small nuclear ribonucleoprotein G-like protein
chr5_+_149131695 0.382 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr10_+_123744131 0.379 TACC2
transforming, acidic coiled-coil containing protein 2
chr7_-_143622233 0.376 ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr6_+_7524691 0.375 DSP
desmoplakin
chr4_-_170314382 0.375 SH3RF1
SH3 domain containing ring finger 1
chr12_-_10983072 0.374 NM_023922
TAS2R14
taste receptor, type 2, member 14
chr3_+_48239865 0.372 NM_004345
CAMP
cathelicidin antimicrobial peptide
chr5_-_124108672 0.371 NM_020747
ZNF608
zinc finger protein 608
chr3_+_46594079 0.371 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr11_-_102250876 0.370 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr4_-_41445693 0.370 NM_003924
PHOX2B
paired-like homeobox 2b
chr2_+_28892366 0.370 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr11_-_13474101 0.369 NM_000315
PTH
parathyroid hormone
chr4_-_47709717 0.369 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr15_+_78139098 0.367 ZFAND6
zinc finger, AN1-type domain 6
chr1_-_116184846 0.366 NM_001111061
NHLH2
nescient helix loop helix 2
chr15_+_32425357 0.364 NM_175741
C15orf55
chromosome 15 open reading frame 55
chr14_-_80934523 0.362 NM_033104
STON2
stonin 2
chr15_+_78139073 0.362 NM_019006
ZFAND6
zinc finger, AN1-type domain 6
chr7_+_111850367 0.362 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr18_-_55136673 0.361 NM_181654
CPLX4
complexin 4
chr4_+_88973144 0.358 NM_001184695
NM_001184696
NM_001184697
NM_020203
MEPE



matrix extracellular phosphoglycoprotein



chr13_+_22653059 0.357 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr5_-_88004891 0.355 LOC645323
hypothetical LOC645323
chr15_+_87540238 0.354 ABHD2
abhydrolase domain containing 2
chr7_-_143523582 0.354 NM_001003702
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr6_+_100161370 0.353 NM_021620
PRDM13
PR domain containing 13
chr5_+_115415061 0.353 NM_001195581
LOC644100
hypothetical LOC644100
chr1_+_158426908 0.353 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr9_-_112139908 0.352 NM_001003936
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr6_+_50789215 0.352 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr2_+_113546365 0.351 NM_032556
IL1F10
interleukin 1 family, member 10 (theta)
chr12_-_4624536 0.349 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr14_-_94677807 0.348 NM_030621
DICER1
dicer 1, ribonuclease type III
chr10_-_128199986 0.347 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chrX_-_119329307 0.346 FAM70A
family with sequence similarity 70, member A
chr12_+_100512877 0.346 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr2_+_61243132 0.343 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr15_-_74941339 0.343 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr6_+_152053323 0.343 NM_001122742
ESR1
estrogen receptor 1
chr2_-_70634129 0.341 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr5_+_72504778 0.340 NM_153217
TMEM174
transmembrane protein 174
chr5_-_134290789 0.339


chr11_-_85146691 0.339 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr12_+_12115139 0.338 NM_138723
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr1_-_51660328 0.336 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr12_+_52696908 0.335 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr7_+_38984133 0.334 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr10_-_74863303 0.333 NM_001024593
ZMYND17
zinc finger, MYND-type containing 17
chr2_-_171631728 0.333 NM_001136555
TLK1
tousled-like kinase 1
chr2_-_215957927 0.333 FN1
fibronectin 1
chr5_+_140772691 0.332 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr6_-_133120587 0.331 NM_004665
VNN2
vanin 2
chr17_+_38306339 0.331 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr16_+_70654625 0.331 NM_020995
HPR
haptoglobin-related protein
chr19_+_52113772 0.330 NM_004491
GRLF1
glucocorticoid receptor DNA binding factor 1
chr20_+_31613800 0.326 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr17_-_74085070 0.326 NM_173628
DNAH17
dynein, axonemal, heavy chain 17
chr10_-_33264491 0.325 NM_033668
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr17_-_36403910 0.325 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr4_-_186814852 0.324 SORBS2
sorbin and SH3 domain containing 2
chr10_-_123343761 0.322 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr6_+_31059463 0.322 NM_001010909
MUC21
mucin 21, cell surface associated

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.49 3.36e-02 GO:0006955 immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.27 8.57e-03 GO:0005576 extracellular region

Nothing significant found in function category.